Experimental Medicine Training Initiative
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Cambridge University
Cambridge University


Cardiovascular Drug Discovery

01/11/2017 to 01/11/2017

We are pleased to announce the next event in the EMI event calendar, jointly funded and delivered with the Cardiovascular Strategic Research Initiative.

Learning objectives:
Understanding the changing landscape of drug discovery process and cardiovascular-specific challenges
Learning effective ways to overcome barriers to drug discovery research
Understanding of how to create and manage academic-industrial collaborations

We have a stellar list of contributors to the day to encourage case study discussions around CV Toxicology, Hypoxia, PAH, Stroke, and Founding a start-up company with Professor Margaret Ashcroft, Professor Richard Farndale, Dr Stephanie Jung, Dr Thomas Krieg, Professor Nick Morrell, Dr Andrew Murray, Dr Sanjay Sinha and Dr Takahiro Yamamoto. Industrial responses will be given by representatives from AstraZeneca and GSK with further contributions from the Cambridge Academy for Therapeutic Sciences, Cambridge Enterprise and Office for Translational Research.

Application to Royal College of Physicians CPD accreditation code 113563 (7 credits)
Please register to confirm a space.

DATE: Wednesday 1st November 2017
TIME: 08.30am - 4.30pm
VENUE: Homerton College followed by dinner at Trinity Hall from 6.30pm (optional)

The objective is to deliver an interactive programme through pairs of researchers (academic + industrial) presenting case studies, followed by challenges, response and discussion by the delegates. We will a) increase awareness of roadblocks or challenges in the drug development process, b) identify ways to overcome them, and c) promote the formation of academic-industrial collaborations.

This event is subject to cancellation fees by the host venue therefore any no-shows or non-attendance of registrants will be charged for and any registration fee collected will be non-refundable.


Day 1 | Wednesday 01 November 2017

Time Item
08:30 to 09:00 Registration & Refreshments
Alison Shrubsole Room
09:00 to 09:30 The path from first idea to a clinical study: challenges and principles
Dr Colin Fish, VP, Translation Platform Project Specialist Group, (GSK)
09:30 to 13:00 CASE STUDIES
Audience participation and contribution to the discussion and debate is required in these sessions. Explore challenges and pitfalls in context with a specific case and real-time events.
09:30 to 10:00 Case Study 1: Prof Nick Morrell “Targeting BMPR2 for the treatment of pulmonary arterial hypertension” Response: Dr David Budd
10:00 to 10:30 Case Study 2: Prof Margaret Ashcroft & Dr Andrew Murray “Mitochondrial/CV toxicity/hypoxia” Response: Dr Jon Lyon (GSK)
10:30 to 11:00 Case Study 3: Dr Takahiro Yamamoto “Cardiovascular toxicity” Response: Dr Nick Edmunds (AstraZeneca) “Physiologically-based PKPD models to predict drug-induced haemodynamic responses in health and disease”
11:00 to 11:30 Break
Networking with colleagues from Office for Translational Research, CATS, Entrepreneurs-in-Residence, Cambridge Enterprise, Milner Institute, Bayer, and local biotech.
11:30 to 12:00 Case Study 4: Prof Richard Farndale & Dr Stephanie Jung “Novel drug targets in AF/stroke” Response: Dr Mark Bamford (GSK)
12:00 to 12:30 Case Study 5: Dr Thomas Krieg “Starting up a company” Response: Dr Rajan Jethwa (Erudite Evolution)
12:30 to 13:00 Case Study 6: Dr Sanjay Sinha “Complex human models of disease to guide patient-specific therapies: Marfan syndrome as an exemplar” Response: Audience
13:00 to 14:00 Lunch
Networking with colleagues from Office for Translational Research, CATS, Entrepreneurs-in-Residence, Cambridge Enterprise, Milner Institute, Bayer, and local biotech.
14:00 to 15:00 CHALLENGE DISCUSSIONS Small group discussions about challenges raised
Led by the case study presenters and challengers the audience are asked to participate to identify possible ways to overcome presented challenges.
15:00 to 16:00 Panel discussion and summary of ideas and follow up steps for each case study.
Panel of University and Industry partners
16:00 to 16:15 Reflection, review and close
Professor Nick Morrell and Dr Paula Frampton (CATS)
16:15 to 18:00 Networking and refreshments
Networking with colleagues from Office for Translational Research, CATS, Entrepreneurs-in-Residence, Cambridge Enterprise, Milner Institute, Bayer, and local biotech.
18:30 to 19:00 Trinity Hall, Chetwode Room - Drinks Reception
Dinner registrants only
19:00 to 22:30 Trinity Hall, Leslie Stephen Room - Dinner
Dinner registrants only


Meeting Details

Homerton College

Parking is not available at the venue. There are multiple park and ride sites, train and bus links to Central Cambridge. Trinity Hall is a short walk from the bus station and about 20 minutes from the train station. Please go to the following link for public transportation links, cycle routes, park and ride and local parking facilities.


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